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By controlling the enzyme, sildenafil can help to take care of an erection once the penis is stroked. With out physical action into the penis, which include that occurring all through sexual intercourse, sildenafil will likely not function to result in an erection.
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Inhibitors of CYP3A4 for instance cimetidine and erythromycin are very likely to minimize sildenafil clearance. CYP3A4 inducers for instance rifampicin may possibly decrease the plasma concentrations of sildenafil. Symptomatic hypotension when utilised with α-blockers. Plasma concentrations are increased by ritonavir.
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